MMustafa
Sep 13, 2011
Graduate / Statement of Intent for Masters of Science, Physiology [5]
I haven't finished but I wanted to get your feedback on what I have written so far.
To Whom It May Concern:
Desiderius Erasmus once said Give light, and the darkness will disappear of itself. Though I believe he was referring to the spiritual aspect of life, it can be applicable to the understanding of human physiology. The light, a symbol for understanding, can overcome the darkness, being something we often dread, which is the fear of a disease. This comprehension is dependent upon our knowledge of normal human functioning. If we know how a normal body works, the missing element in the abnormal body can be effortlessly deduced. This is where research plays an essential role.
Although the human kind is yet to discover a cure for Alzheimer Disease (AD), we have actively assembled an exceptional understanding of its effect. We have acquired the knowledge of its cause being neurofibrillary tangles and beta amyloid plaque. However, we have yet to detect the disease in its early stage, dementia. If this can be performed, we can start the patient on medications, preserving the vast amount of neurons in the transentorhinal cortex. This was the understanding used when developing my research project with Dr. Boyer Winters. I successfully developed a rodent model of Delayed Matching to Position (DMTP) task, to ensure the rodents can spatial distinguish each arm of the maze. This task formed the foundation for Paired Associate Learning (PAL) task, which associates visual and spatial memory. This is often severed in AD patients. After such task is developed, the rodents memory will be impaired by scopolamine, and with the efforts of trial and error, the treatment will be formulated.
I haven't finished but I wanted to get your feedback on what I have written so far.
To Whom It May Concern:
Desiderius Erasmus once said Give light, and the darkness will disappear of itself. Though I believe he was referring to the spiritual aspect of life, it can be applicable to the understanding of human physiology. The light, a symbol for understanding, can overcome the darkness, being something we often dread, which is the fear of a disease. This comprehension is dependent upon our knowledge of normal human functioning. If we know how a normal body works, the missing element in the abnormal body can be effortlessly deduced. This is where research plays an essential role.
Although the human kind is yet to discover a cure for Alzheimer Disease (AD), we have actively assembled an exceptional understanding of its effect. We have acquired the knowledge of its cause being neurofibrillary tangles and beta amyloid plaque. However, we have yet to detect the disease in its early stage, dementia. If this can be performed, we can start the patient on medications, preserving the vast amount of neurons in the transentorhinal cortex. This was the understanding used when developing my research project with Dr. Boyer Winters. I successfully developed a rodent model of Delayed Matching to Position (DMTP) task, to ensure the rodents can spatial distinguish each arm of the maze. This task formed the foundation for Paired Associate Learning (PAL) task, which associates visual and spatial memory. This is often severed in AD patients. After such task is developed, the rodents memory will be impaired by scopolamine, and with the efforts of trial and error, the treatment will be formulated.